Kongress 2021 Tumor microenvironment as biotope? Inflammation, angiogenesis, metabolisms as targets for chemoprevention
Introduction: A healthy lifestyle and diet have long been associated with smaller chances of developing non-familial malignancies. In recent years, research studies have turned this common
sense-based concept into the proper strategy of chemoprevention, i.e. actively applying welltolerated dietary supplements in order to reduce the risk of cancer formation or recurrence. Many
natural compounds commonly found in foods and beverages (flavonoids such as carotenoids, green tea catechins...) as well as drugs used for other clinical practices (aspirin, metformin....) have been recognized as capable of preventing or retarding tumour development and progression. Several of these molecules attain chemopreventive effects by curbing angiogenesis, a crucial event in cancer progression. Olive mill wastewaters (OMWWs), a waste product from olive oil industry, are rich in polyphenols, particularly hydroxytyrosol (HT), known to possess anti-inflammatory and antioxydant properties. Xanthohumol (XN), the most abundant flavonoid in the hop plant (Humulus lupulus L), is also an antioxydant polyphenol and can be found in beer. Metformin, an anti-diabetic drug commonly used in type 2 diabetes patients, has been associated with decreased cancer risk in epidemiological studies.